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HIF-1 forms a heterodimer with HIF-1 in the cytoplasm, translocates into the nucleus, and binds specific HREs on DNA, where it acts as a transcription factor for the downstream target gene VEGF ( Figure 3E )

Zhao, Y., Simon, M., Seluanov, A

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

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Salz nach Anspruch 1 oder 2, wobei Xaa Ala, bAla, Leu, Ile, Gly, Val, Nle oder Nva ist, Yaa Lys, Arg, Orn oder His ist und Zaa Glu, Asp, Aad oder Amp ist