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There was a tendency toward higher t 1/2 with increasing hepatic impairment, but applying the same rationale as stated above for participants with renal impairment, this was not considered clinically relevant

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The evidence-based approach is to follow your titration schedule or move to your next dose increase if your provider determines you're ready, not to accelerate by taking multiple doses in one week

doi:10.1007/S11892-015-0602-9 6

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