Second, GLP-1 activation influences immune signaling pathways, including those that regulate histamine release and inflammatory cytokinesmolecules that promote itching at the skin level
N Engl J Med 264:226, 1961
It happened to the anti-reflux drug omeprazole and even the allergy drug fexofenadine

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Anders Fink-Jensen at Copenhagen University Hospital and including NIH scientists, studied the effects and safety of the GLP-1 semaglutide in people seeking treatment for AUD who also had obesity