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Of relevance, recent evidence indicates that SAM exerts anti-inflammatory effects by reducing the expression of the proinflammatory cytokine tumor necrosis factor-alpha (TNF) and increasing the expression of the anti-inflammatory cytokine interleukin 10 (IL-10)

PLoS ONE 6 , e20912 (2011)

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Formularies will often organize covered drugs into tiers, with generics in the lowest tier and more specialty or brand-name drugs in the higher ones