This division underscores the complex considerations behind coverage decisions, as stakeholders weigh the clinical realities of obesity against beliefs about personal responsibility and concerns about long-term benefit
Youth with type 2 diabetes, hypertension, fatty liver disease, or sleep apnea show stronger benefit from GLP-1 therapy than those with isolated obesity

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Newer research suggests the muscle loss concern may have been overstated in some early studies
Heine RJ, Van Gaal LF, Johns D, et al