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In one melanoma study, mice exposed to higher NAC doses experienced greater metastatic activity than those given lower doses, suggesting the effect may be dose-dependent in certain experimental settings.42 Researchers have not established whether these findings apply to humans, but starting with a moderate dose offers a more conservative approach while still aligning with a large portion of the clinical literature

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The transappendageal delivery follows the penetration through a diffusional shunt provided by the hair follicles or the pilosebaceous unit [290, 322]