Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the g-protein-coupled receptor ffar2
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White adipose tissue in these mice had a unique immunophenotype, with increased proinflammatory macrophages and dysfunctional Tregs, suggesting a mechanism for adiposity distinct from those of typical obesity models
Potential mediators of increased postprandial serotonin levels in PBH could include increased numbers of serotonin-secreting enterochromaffin cells, or increased release of serotonin by these same cells, potentially linked to alterations in luminal contents (56)
In participants with obesity or overweight, withdrawing tirzepatide led to substantial regain of lost weight, whereas continued treatment maintained and augmented initial weight reduction [75]
