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People on the highest dose lost up to 7.9% of their starting body weight over 40 weeks

Accordingly, one of the most remarkable central effects of GLP-1R signaling occurs in neuronal populations involved in the control of caloric intake by promoting anorexigenic effects

Sanofi US 2022.

It has been hypothesized that when gluten is digested, opioid peptides called gluteomorphins are released into the gastrointestinal tract and taken up into the bloodstream