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The following adaptogens are recommended: Ashwagandha (Withania somnifera) 250 mg of standardized extract once or twice daily (Stengler 2016) Extract doses can range from 225 to 1,250 mg per day for 6 to 8 weeks to reduce feelings of stress and anxiety and to decrease fatigue, sleeplessness, and stress hormone levels (ODS 2023

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Clinical trials suggest that GLP-1RAs may reduce serum androgen levels, enhance ovulatory function, and support menstrual cycle normalization

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Longer use carries cumulative organ hypertrophy and cancer-proliferation concerns