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A randomized trial in healthy Japanese men demonstrated that E6011 was safe and well tolerated, although its efficacy in PBC remains unexplored (85)

Ophthalmology 98 , 16741678 (1991)

Depletion of the brain antioxidant glutathione (GSH) may be important in OS-mediated neurodegeneration, though studies of post-mortem brain GSH changes in AD have been inconclusive