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Compared to cognitively normal older adults, cerebrovascular resistance is higher in individuals with MCI and ADRD, and has been associated with greater A burden, cortical atrophy, and risk of progression to ADRD (Yew and Nation, 2017)

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Clinical trials such as SURPASS have demonstrated Tirzepatides ability to significantly reduce HbA1c levels (a marker of long-term blood glucose control) and induce substantial weight loss in patients with type 2 diabetes