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Therapeutically, p53 activation dualistically regulates apoptosis and ferroptosis to suppress PCa growth, but ferroptosis-driven macrophage polarization in the TME may inadvertently promote tumor metastasis [Figure 2A], emphasizing the need for context-specific modulation to balance efficacy and paradoxical outcomes

Nature 468 , 701704 (2010)

Long-term alcohol intake-induced hepatic oxidative stress and inflammatory responses can be alleviated, and liver iron metabolism can be improved by inhibiting RAGE expression

Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study