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10.1210/er.2014-1035 23 SarkarS.BalharaY
[DOI] [PubMed] [Google Scholar] Ozturk O, Eroglu HA, Ustebay S, Kuzucu M, Adali Y
doi: 10.1093/emboj/17.17.4987
Indeed, in a mouse model recapitulating features of human melanomagenesis, it has been shown that mature MCs expressing a B-Raf oncogene can undergo transcriptional reprogramming, associated with a loss of their differentiated characteristics and eventual invasion into the dermis (Khler et al, 2017)
TRAP staining revealed a similar number of osteoclasts in MSC- Igf1r / mice compared to their wildtype littermates (Figure 5, bottom panel), further indicating that the decreased bone volume observed by CT was due to decreased bone formation rather than enhanced bone resorption
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