20% increase in natural GLP-1 level Blood glucose improvement (HbA1c, FBG, HOMA-IR) 24% prediabetic subjects back to normoglycemia PROVEN COMPATIBILITY with Metformin Randomized, Double-blind, Placebo-controlled, Crossover Trial 36 prediabetic subjects (18 - 65 years old) American Diabetes Association (HbA1c = 5.7 - 6.4%) Group A = 250mg Eriomin + 1000mg Metformin Group B = Placebo + 1000mg Metformin Clinically Demonstrated Efficacy Preserve Active GLP-1 Level Active GLP-1 are prone to inactivation by DPP-4 enzymes, inactivated GLP-1 cannot perform its function Effective Glucose Clearance Eriomin group has significant lower blood glucose level at both 60 min and 120 min Eriomin exhibited synergistic effect in combination with metformin , indicating potential for improved efficacy without an increase in adverse effects
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However, in the latest guideline of American Diabetes Association (ADA 2023), the effect on major cardiovascular episodes (MACE) of metformin remains potential [9]
