Equally revealing was the observation that the NADH/NAD couple, which slowly interacts with the GSH system (Rost and Rapoport, 1964), could not substitute for NADPH/NADP in the enzyme-catalyzed system (Rall and Lehninger, 1952), although the redox potentials of the two nucleotide couples are practically identical
8 In addition, p53 represses mTOR signaling by upregulating the upstream inhibitors AMPK, TSC2, PTEN , and SESN1/2 , thus increasing autophagic flux
Lack of effect of oral sulforaphane administration on nrf2 expression in COPD: a randomized, double-blind, placebo-controlled trial
In this study, we investigated the regulation of the TSS pathway in SCD erythroblasts under hypoxia and excess hemin exposure conditions
Cell proliferation induced by GPE was further delineated by an increased level of phosphorylated Akt, indicating potential upregulation of the ERK ( Figure 6 ) and PI3K/Akt signaling pathways ( Figure 7 ) pathways, which are among the signaling pathways involved in the regulation of cell proliferation
