The traditional classification of DM is mainly based on abnormalities in insulin secretion and action, such as type 1 DM due to an absolute lack of insulin secretion and T2DM due to insulin resistance and relative insulin deficiency
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By staying below the smallest available commercial dose and extending dosing intervals to 10, 14, 21, or 28 days, providers can deliver meaningful metabolic benefit with dramatically better tolerability and adherence
With this rationale, a study used the IMS Centre for Outcomes Research and Effectiveness (CORE) Diabetes Model (a nonproduct-specific diabetes policy analysis tool that performs real-time simulations developed by IMS Health, Danbury, CT, USA) to examine the impact of improved glycemic control in patients with T2D [62]
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