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Glutathione nasal spray primarily targets the nasal mucosa, sinuses, and brain , with some systemic absorption as well

Further, SAR experiments focused on residue-by-residue optimization of 1907 to identify residues that were critical to activity

However, it does not correct the underlying cystic fibrosis transmembrane conductance regulator defect, as shown by the lack of improvement in nasal transepithelial potential difference in cystic fibrosis transmembrane conductance regulator-deficient mice, indicating that epithelial ion transport remains impaired

Qi F, Jeong K-J, Gong J, Tang Z

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