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There are so many questions to which we currently dont know the answers

As body weight decreases, calorie needs often change, and the body may adapt to a lower weight over time

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However, they also contribute to some of the side effects, which will be discussed later in the article

Further reciprocal mutagenesis studies will be required to identify key interactions responsible for the contrasting effects of exendin-phe1, exendin-asp3 and other analogs, facilitating future design of agonists with even greater selectivity