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This evidence indicated that there appears to be a relationship in the pathogenesis of autism between VPA-induced autism and MECP2-deficient autism, suggesting the potential shared downstream pathogenic molecular mechanisms

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In order to reconcile short comings and difficulties in accurately defining and classifying the severity of HE, in 1998 the World Organisation of Gastroenterology introduced a multiaxial definition of HE [5], which categorized HE according to