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In research settings, theyre commonly studied for their potential in areas similar to cellular signaling, molecular interplay, and biochemical exploration

Sample sizes were generally small (median: 48, IQR 2594), reflecting both the rarity of the diseases studied and the exploratory nature of early-stage research

Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly

The pelvic floor muscles are a group of muscles that run from the coccyx to the pubic bone

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