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Though we did not observe differences in total astrocyte or myelin protein expression, we noted an increase in Iba1, reflective of increased microglia

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Geetika Arora, an endocrinologist at Northwell's Phelps Hospital, puts it simply: "The trade-off comes down to convenience versus maximum weight loss." In a Lilly-funded trial published by The Lancet, patients on 12 to 36 milligrams of orforglipron lost an average of 15 to 20 pounds, compared with 8 to 11 pounds for those on 7 to 14 milligrams of Rybelsus

The GLP-1 Gap: Body Composition GLP-1 therapies from Novo Nordisk, Lilly, and others have demonstrated unprecedented weight-loss efficacy, but Brenner emphasized that weight reduction can come with a meaningful trade-off