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PRL levels within the physiological or metabolic range can promote -cell proliferation and survival, improve insulin sensitivity, inhibit gluconeogenesis, optimize lipid distribution, and reduce the risk of fatty liver disease ( 7 Clinical implications and future directions 7.1 Therapeutic considerations in patients with obesity and hyperprolactinemia Currently, weight management strategies are divided into three categories: lifestyle interventions, drug therapy, and metabolic/bariatric surgeries
Our observations about the efficacy of GLP-1 RAs in enhancing survival and reducing cardiovascular events are concordance with evidence from several cardiovascular outcome trials (CVOTs) conducted in general population with T2DM, as well as a recent cohort study focused on solid organ transplant recipients [16,17,18,19, 23]
Focus on whole foods including lean proteins, vegetables, healthy fats in moderate quantities, and complex carbohydrates
The clinical data is strong
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