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A double-blind, randomized, placebo-controlled trial in 130 PCOS patients showed the combination of letrozole plus 1,200 mg NAC per day resulted in more follicles greater than 18 mm in diameter (a size associated with greater likelihood of ovulation) after five days than letrozole alone or placebo

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This insight may help provide context about your metabolic predisposition and can support a more personalized conversation with a provider about whether medication-supported management is appropriate for you