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CMA is conventionally regarded as a pro-survival mechanism, activated under conditions such as starvation, and dependent on both HSP70swhich bind client proteinsand HSP90s, which stabilize LAMP2A (Tekirdag and Cuervo, 2018)

Yet B12 deficiency is remarkably common, affecting vegetarians, vegans, older adults, and anyone taking certain long-term medications like metformin or proton pump inhibitors

Mitochondrial Decline Lower cellular energy means slower healing and more signs of aging

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J Colloid Interface Sci 600:412420 Gopalakrishnan A, Raju TD, Badhulika S (2020) Green synthesis of nitrogen, sulfur-co-doped worm-like hierarchical porous carbon derived from ginger for outstanding supercapacitor performance