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The Independent Validation That Matters One piece of evidence that doesn't get enough attention: in July 2025, a completely independent research group not affiliated with Fractyl published a peer-reviewed study in Nature's Communications Medicine demonstrating that a single genome-editing intervention targeting liver cells could produce sustained GLP-1 receptor agonist secretion

doi: 10.1016/j.mce.2016.09.006 65 HenaganTMStefanskaBFangZNavardAMYeJLenardNRet al

As described above, GLP-1RAs attenuate albuminuria and marginally reduce eGFR decline

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The Sikiric groups foundational research, published in major pharmacology journals and indexed at the NIH National Library of Medicine, demonstrates direct gastroprotective and anti-inflammatory action in the gut mucosa