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It also carries an increased risk of a second cancer developing in the treated site

Recommended dosage and administration As clinical research on DSIP is still limited, definitive dosing guidelines have not been established

This is in comparison to synthetic sources such as Hydroquinone, which is said to be unsafe and leads to liver damage If we explore this a bit further however, we are aware that under certain alkaline conditions, natural arbutin can still convert into Hydroquinone, which means that it becomes unsafe in some circumstances

Lysates were centrifuged at 14,000 rpm for 15 min, and protein concentration was determined using the BCA kit (Thermo Fisher, 23227)