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You might think you are injecting 5 mg but you are actually injecting 3.5 mg

PMID 1851003

A Novel Machine Learning Approach to Predicting Brain Cancer Survival Time using Hot Encoding, Vikrant Mahajan, Palash Shah 65

Finally, while Eggers test and trim-and-fill analysis did not suggest substantial publication bias, the possibility of undetected bias remains, especially given the limited power of these tests when few studies are included