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The number of investigations on the identification and isolation of equine antimicrobial peptides during the last decades is pretty small
Up to 9% of patients who receive the intravenous antidote experience anaphylactoid reactions, triggering symptoms of flushing, pruritus, rash, and, rarely, bronchospasm and hypotension
All research must be conducted under appropriate ethical oversight and regulatory compliance with institutional review board approval where applicable
Prolonged suppression also increases the risk of desensitization to IGF-1 signaling itself, potentially reducing anabolic responsiveness
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