They are support, not enhancement
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FUNCTIONAL ANNOTATION: PRINCIPLES AND APPLICATIONS IN OMICS STUDIES Functional annotation refers to the process of assigning biological information to genomic elementsgenes, proteins, or metabolitesbased on sequence similarity, evolutionary conservation, or curated biological knowledge
Horm Mol Biol Clin Investig
Therefore, even though the upper limit of the laboratory reference range has changed, the lower end of the reference range remains the same