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532 Upon receiving certain cues, cancer stem cells can differentiate to give rise to the cancer cells or cancer cells can de-differentiate back to their CSC state

According to the Mayo Clinic, this means excess blood may back up in the legs, ankles, and feet, leading to edema

However, whereas the majority of hepatotoxic compounds cause centrilobular injury, some xenobiotics, such as allyl formage, elemental phosphorus, and allyl alcohol, preferentially damage periportal hepatocytes, presumably as a result of rapid first-pass uptake by these upstream hepatocytes

Maintain a Balanced Diet: Reduce sodium intake and eat kidney-friendly foods

However, its important for patients to work closely with their healthcare providers to ensure safe and effective use of this medication