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Alterations in Mitochondrial DNA Copy Number and the Activities of Electron Transport Chain Complexes and Pyruvate Dehydrogenase in the Frontal Cortex from Subjects with Autism

Notably, the majority of mechanistic data supporting this concentration-dependent model derives from preclinical studies using mouse pancreatic -cells and clonal cell lines, with limited validation in human islet studies, necessitating further clinical investigation to confirm these concentration thresholds in human diabetes treatment [23,24,25,26]

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