The key difference comes down to bioavailability, which is how much of a nutrient your body can actually absorb and use
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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. In semaglutides extension, about two-thirds returned within one year. The pattern reflects removal of appetite suppression after major weight loss
However, when they added 1.5 g per day of lysine to their existing iron supplementation, there was a significant increase in mean serum ferritin concentrations, and the women experienced a 39 percent decrease in hair shedding after six months of treatment
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