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Metformin acts on two different molecular pathways to enhance adult neural precursor proliferation/self-renewal and differentiation

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The main chain amide and carbonyl groups of the C residue of GSH form additional H-bonds with the side chain of the carbonyl oxygen of D150, and the side chain of Q155, respectively (both protomer B)

Bain, Swansea University Medical School, Swansea, UK

Manage Side Effects Promptly If you experience: Mild nausea Eat light meals & try Emetrol (available at most drugstores) Constipation Drink more water, increase fiber, or take a mild laxative Any concerns