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In the skin, Vitamin D synthesis begins with the photolysis of 7-dehydrocholesterol (proVitamin D) in the plasma membrane of keratinocytes, forming preVitamin D [59]

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Contrary to these results another group observed that suppression of ME1 in isolated rat islets did not have an impact on GSIS, although suppression of this enzyme in the INS-1 832/13 cell line yielded results similar to the two previous studies [44]