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When combined with the exclusion of patients with either acute or chronic pancreatitis from prior clinical trials, this observation aligns with the caution raised by the American Diabetes Association to avoid use of GLP-1RAs for patients with any history of acute or chronic pancreatitis 27

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Xigduo XR Dosage and Administration 2.1 Testing Prior to Initiation of XIGDUO XR Assess renal function prior to initiating XIGDUO XR and then as clinically indicated [see Warnings and Precautions (5.1, 5.3)]