Semaglutide is a glucagon-like peptide 1 receptor agonist, also called a GLP-1 medication
Cell Mol Neurobiol 36:203217 Min T, Bain SC (2021) The role of tirzepatide, dual GIP and GLP-1 receptor agonist, in the management of type 2 diabetes: the SURPASS clinical trials
Although rates of acute pancreatitis have been low and similar between GLP-1 agonists and placebo in studies, caution is still warranted since acute pancreatitis carries a risk of recurrencewhich can turn into chronic pancreatitiswhich can increase risk of pancreatic cancer
More recently, the possibility that GLP-1 mimetics predispose to pancreatic cancer has been raised and disputed (38, 82)
Platycodin-D can induce autophagy in H460 and A549 NSCLC cells, as shown by stimulating the formation of ATG3, ATG7, Beclin-1, and LC3-II (255)