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Notably, alanine substitution studies indicate that R 299 , W 306 , and E 373 of GLP-1R contribute to the binding affinity and potency of GLP-1
The objective response rate was 32% (95% CI, 23%41%), with four complete responses and 34 partial responses as assessed by RECIST 1.1 criteria and an independent central review
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Compared with traditional small-molecule drugs, GLP-1 peptides are structurally more complex and can exist in multiple molecular forms
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