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In summary, recent CV outcomes trials with GLP-1RAs have shown promising benefits in CV care of T2D patients, and GLP-1RAs have been accordingly listed as a second line therapy in T2D patients with established atherosclerotic CV disease, alongside SGLT2 inhibitors [5, 6]

(n.d.) GLP-1 agonists

Dhalla AK, Al-Shamsie Z, Beraki S, et al

Mechanistically, PT141: Acts as an agonist at melanocortin4 (MC4R) and melanocortin1 (MC1R) receptors, with primary relevance to sexual behavior and energy balance through MC4R in the CNS and additional roles in pigmentation, inflammation, pain, and infection via MC1R

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