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The carcinogenic properties of estrogen are partly attributed to the production of quinones and semiquinones from 2- and 4-hydroxyestrogens that form depurinating DNA adducts and cause double-strand breaks in DNA 17

Applying REWIND cardiovascular disease criteria to SUSTAIN 6 and LEADER (REWIND trial reference)

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Meissner WG, et al

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After completion of normalization processes, counts were log2 transformed, and a build ratio analysis was performed by comparing the expression profiles of EV AML -treated CD34 + cells and control (vehicle) CD34 + cells