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Nasal administration is of interest in peptide research because it avoids gastrointestinal degradation and first-pass hepatic metabolism, allowing researchers to observe more direct peptide transport and interaction kinetics

Diabetes 51(6):19381948 Frustaci A, Chimenti C, Setoguchi M, Guerra S, Corsello S, Crea F, Leri A, Kajstura J, Anversa P, Maseri A (1999) Cell death in acromegalic cardiomyopathy

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Statements Author contributions QL: Conceptualization, Data curation, Formal analysis, Writing original draft, Writing review & editing

We follow guidelines from the FDA and Endocrine Society, which recommend that GLP-1 agonists be used alongside healthy eating, increased physical activity, and behavioral changes for the best results