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The use of the letter E ( Energy) is preferred over C ( Calorie) to avoid potential confusion with carbohydrates rather than caloric intake

Since the latter are thought to exert their glucose-lowering activity by preventing the degradation and inactivation (with regard to insulinotropic effects) of endogenously released intact, biologically active GLP-1 [9], their pharmacological action should critically depend on availability of the major substrate, GLP-1

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From a regulatory perspective, inconsistencies across jurisdictions regarding the classification of probiotics, the evidentiary requirements for claims, and manufacturing and quality control standards contribute to variability in product quality and the potential for misleading labeling (526)

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