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Proteomic profiling Proteomic analysis of pooled seminal samples from the fertile donor cohort ( n = 5) and patients with idiopathic primary infertility ( n = 5) led to the identification of 1,134 proteins overall, with a subset of 141 proteins was present exclusively in the fertile donor group, nine proteins were present exclusively in patients with idiopathic primary infertility and 344 proteins were deferentially expressed (as described in the Supplementary Material A) with 235 proteins underexpressed and 109 proteins overexpressed

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