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This was particularly evident in the mitochondrial proteins responsible for detoxifying H 2 S, and this downregulation was associated with a higher disease severity (70)

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Metabolomic profiling revealed that the granules modulated several key metabolic pathways, including purine metabolism, thereby offering important leads for target identification [542]

In this review, we elucidate in detail the molecular mechanisms and potential roles of both autophagy and necroptosis in CP-induced AKI

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