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Inclusion Criteria Exclusion Criteria Timeline for a Trial Participant Screening Participants are screened for eligibility to participate in the trial Treatment Participants receive weekly subcutaneous injections of either CagriSema or Tirzepatide, with a dose escalation period followed by maintenance dosing Follow-up Participants are monitored for safety and effectiveness after treatment What Are the Treatments Tested in This Trial

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Lactobacillus helps repair the intestinal epithelial barrier by upregulating tight junction proteins and reduces colonic inflammation in UC mice by inhibiting the TLR4-NF-B-NLRP3 signaling pathway [42, 43]