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Reinitiation rates were also lower among non-T2DM patients, reinforcing challenges in long-term adherence and access to GLP-1 therapies

However, there persist key unmet needs facing this treatment landscape, with varying levels of complexity

Despite this complexity, current treatments predominantly focus on BMI thresholds with little consideration for individual phenotypes or response variability (68)

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Besides, B-GOS supplementations elevated NMDA receptor components (GluN1 protein and GluN2A mRNA) of the brain essential for cognitive functions besides raising the inflammatory marker TNF in combination with olanzapine as a factor toward weight gain reduction