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A 12-week facial cream study in 71 women with mild to advanced photoaging showed increased skin density and thickness, reduced laxity, improved clarity, and reduced fine lines and wrinkle depth with strongly stimulated dermal keratinocyte proliferation

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Cornier M-A, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Van Pelt RE, Wang H, Eckel RH

[48] and included patients who were 18-120 months after RYGB and had regained 10% of total body weight loss after reaching their nadir weight

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