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However, therapeutic application of PXR and CAR agonists faces caveats: (1) species-specific differences in receptor activation limit direct translation from rodents to humans

Transplantation Nude mice were covered with betaine solution under anesthesia

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the data from these two large, well-powered clinical trials will provide robust evidence on the cardiovascular and metabolic benefits of tirzepatide, potentially expanding the treatment options for adults with T2DM, obesity, and related cardiovascular complications [7] (Clinical Traials.gov)