Calvarysky B, Dotan I, Shepshelovich D, et al
That triple-receptor approach produced the highest weight loss numbers ever recorded in obesity pharmacotherapy
In addition to blunted monoaminergic neurotransmission, it was also shown that deficiency in neurotrophic factor effects, disturbances in neurogenesis and synaptogenesis, chronic neuroinflammatory processes, and dysregulation of the hypothalamicpituitaryadrenal (HPA) axis can largely contribute to the manifestation of depressive symptoms in patients [3,4,5]
"Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle." Biomedicines , 2025
Overall, these results unequivocally show that the decrease in appetite caused by GLP-1 and GIP mimetics is associated with a significant reduction in body weight