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We should note that this is only a proof-of-concept study conducted on a small group of people

doi: 10.1182/blood-2013-09-512749 70 MeduriGBauseroPPerrot-ApplanatM

The arginine salt formulation shows only 15.1% degradation after 5 hours at pH 3.0, compared to 99% destruction of standard acetate forms under the same conditions

In some embodiments, the otic formulation or composition comprises about 0.04% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Unlike benzodiazepines or other sedatives, it doesn't appear to create tolerance requiring escalating doses or produce withdrawal symptoms upon cessation