It is estimated that the prevalence of obesity and severe obesity in the U.S
Additional staining was performed using an Abcam immunohistochemistry kit for MCP-1 as a measure of general neuroinflammation
All cited studies are conducted in rodent or in-vitro systems consistent with RUO classification

Even intentional weight loss correlates with increased depressive symptomatology among overweight or obese adults in the United States, Journal of Affective Disorders Report (2022) Cross-sectional, case-control and longitudinal associations between exposure to glucagon-like peptide-1 receptor agonists and the dispensing of antidepressants, Diabetes, Obesity, and Metabolism (2024) Diabetes and mental health, CDC (2024) Effect of antidepressants on glucagon-like peptide-1 receptor agonist-related weight loss, Journal of Pharmacy Technology (2022) Efficacy and safety of semaglutide 2.4 mg according to antidepressant use at baseline: A post hoc subgroup analysis, Obesity (2024) Increased incident rates of antidepressant use during the COVID-19 pandemic: interrupted time-series analysis of a nationally representative sample, Psychological Medicine (2022) KFF Health Tracking Poll May 2024: The publics use and views of GLP-1 drugs, KFF (2024) Obese patients taking antidepressants lost weight on semaglutide, Cleveland Clinic Journal of Medicine (2023) Overweight, obesity, and depression: A systematic review and meta-analysis of longitudinal studies, JAMA Psychiatry (2010) Ozempic dosing, Ozempic Wegovy dosing schedule, Wegovy Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

We called patients every 2 weeks to remind them of the supplements and record any side effects